Dr Federico Lucantoni, M.Sc., PhD – Postdoctoral researcher, Royal College of Surgeons, Centre for Systems Medicine

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    • Dr Federico Lucantoni, M.Sc., PhD – Postdoctoral researcher, Royal College of Surgeons, Centre for Systems Medicine's presentations

    Federico is a molecular biologist and postdoctoral researcher in the Royal College of Surgeons in Ireland and Centre for Systems Medicine, under the supervisions of Prof. Jochen Prehn. His research focuses on testing a computational model, previously developed in the department by Dr. Andreas Lindner, to predict chemotherapeutic responses in breast cancer. His project also involves studying how to modulate breast cancer metabolism to stop the progression of this disease.

     

     

    Title: A system modelling approach for personalised medicine in breast cancer

    Synopsis: Triple negative breast cancer is an aggressive form of breast cancer, which accounts for 15-20% of this disease and is currently treated with genotoxic chemotherapy. The BCL2 family of proteins controls the process of Mitochondrial Outer Membrane Permeabilization, which is required for the activation of cell death in response to genotoxic agents. We previously developed a deterministic systems model of BCL2 protein interactions, DR_MOMP that calculates the sensitivity of cells to undergo cell death. Here, we determined whether DR_MOMP predicts responses of triple negative breast cancer cells to genotoxic agents and the re-sensitization of resistant cells by BCL2 inhibitors.

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